The work of the Mucosal and Microbiota Immunology Laboratory directed by Prof. Maria Rescigno at Humanitas Research Hospital will be published in The Journal Of Urology.
The dogma that urine is sterile has been overturned and dysbiosis of the urinary microbiome has been linked to many urological disorders. We tested the hypothesis that the urinary microbial composition may be different between men with or without bladder cancer in catheter-collected urines, bladder washouts and midstream voided urines, and may be dependent on tumor staging.
The results of the work led to find that the bladder is colonized by endogenous bacteria and microbial modifications characterize the microbiome of bladder cancer patients. Different microbial compositions can be characterized by changing sampling strategy. These results pave the way for exploring new diagnostic and therapeutic options based on the manipulation of the bacterial community.