{"id":2470,"date":"2020-02-10T09:58:19","date_gmt":"2020-02-10T09:58:19","guid":{"rendered":"https:\/\/postbiotica.com\/uncategorized\/a-new-manuscript-of-the-laboratory-of-mucosal-immunology-and-microbiota-published-in-nature-microbiology-against-the-development-of-intestinal-tumors\/"},"modified":"2022-06-22T16:13:22","modified_gmt":"2022-06-22T16:13:22","slug":"a-new-manuscript-of-the-laboratory-of-mucosal-immunology-and-microbiota-published-in-nature-microbiology-against-the-development-of-intestinal-tumors","status":"publish","type":"post","link":"https:\/\/postbiotica.com\/en\/news-en\/a-new-manuscript-of-the-laboratory-of-mucosal-immunology-and-microbiota-published-in-nature-microbiology-against-the-development-of-intestinal-tumors\/","title":{"rendered":"A new manuscript of the Laboratory of Mucosal Immunology and Microbiota published in &#8220;Nature Microbiology&#8221; against the development of intestinal tumors."},"content":{"rendered":"<p>The work of the Mucosal and Microbiota Immunology Laboratory directed by Prof. Maria Rescigno at Humanitas Research Hospital and supported by the AIRC foundation, led to the publication in Nature Microbiology of the paper regarding the identification of endogenous antitumor bacterial strains. The results show that some bacterial strains that live inside the microbiota have a brake function against the development of intestinal tumors.<\/p>\n<p>The microbiota has been shown to promote intestinal tumourigenesis, but a possible anti-tumorigenic effect has also been postulated. Here, it is shown that changes in the composition of the microbiota and mucus are concomitant with tumorigenesis. We identified two anti-tumourigenic strains of the microbiota\u2014<em>Faecalibaculum rodentium<\/em>\u00a0and its human homologue,\u00a0<em>Holdemanella biformis<\/em>\u2014that are strongly under-represented during tumourigenesis. Reconstitution of Apc<sup>Min\/+<\/sup>\u00a0or azoxymethane- and dextran sulfate sodium-treated mice with an isolate of\u00a0<em>F. rodentium<\/em>\u00a0(<em>F<\/em>. PB1) or its metabolic products reduced tumour growth. Both\u00a0<em>F<\/em>. PB1 and\u00a0<em>H. biformis<\/em>\u00a0produced short-chain fatty acids that contributed to control protein acetylation and tumour cell proliferation by inhibiting calcineurin and NFATc3 activation in mouse and human settings. We have thus identified endogenous anti-tumourigenic bacterial strains with strong diagnostic, therapeutic and translational potential.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41564-019-0649-5\">https:\/\/www.nature.com\/articles\/s41564-019-0649-5<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The work of the Mucosal and Microbiota Immunology Laboratory directed by Prof. Maria Rescigno at Humanitas Research Hospital and supported by the AIRC foundation, led to the publication in Nature Microbiology of the paper regarding the identification of endogenous antitumor bacterial strains. The results show that some bacterial strains that live inside the microbiota have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1927,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[34],"tags":[],"class_list":["post-2470","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A new manuscript of the Laboratory of Mucosal Immunology and Microbiota published in &quot;Nature Microbiology&quot; against the development of intestinal tumors. - Postbiotica<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/postbiotica.com\/en\/news-en\/a-new-manuscript-of-the-laboratory-of-mucosal-immunology-and-microbiota-published-in-nature-microbiology-against-the-development-of-intestinal-tumors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new manuscript of the Laboratory of Mucosal Immunology and Microbiota published in &quot;Nature Microbiology&quot; against the development of intestinal tumors. - Postbiotica\" \/>\n<meta property=\"og:description\" content=\"The work of the Mucosal and Microbiota Immunology Laboratory directed by Prof. Maria Rescigno at Humanitas Research Hospital and supported by the AIRC foundation, led to the publication in Nature Microbiology of the paper regarding the identification of endogenous antitumor bacterial strains. The results show that some bacterial strains that live inside the microbiota have [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/postbiotica.com\/en\/news-en\/a-new-manuscript-of-the-laboratory-of-mucosal-immunology-and-microbiota-published-in-nature-microbiology-against-the-development-of-intestinal-tumors\/\" \/>\n<meta property=\"og:site_name\" content=\"Postbiotica\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-10T09:58:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-06-22T16:13:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/postbiotica.com\/wp-content\/uploads\/2020\/02\/Microbiologia-della-natura.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"PaoloGiove\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@postbioticasrl\" \/>\n<meta name=\"twitter:site\" content=\"@postbioticasrl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"PaoloGiove\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/postbiotica.com\\\/en\\\/news-en\\\/a-new-manuscript-of-the-laboratory-of-mucosal-immunology-and-microbiota-published-in-nature-microbiology-against-the-development-of-intestinal-tumors\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/postbiotica.com\\\/en\\\/news-en\\\/a-new-manuscript-of-the-laboratory-of-mucosal-immunology-and-microbiota-published-in-nature-microbiology-against-the-development-of-intestinal-tumors\\\/\"},\"author\":{\"name\":\"PaoloGiove\",\"@id\":\"https:\\\/\\\/postbiotica.com\\\/en\\\/#\\\/schema\\\/person\\\/0523776cc37687fb5479c8b07c88fb11\"},\"headline\":\"A new manuscript of the Laboratory of Mucosal Immunology and Microbiota published in &#8220;Nature Microbiology&#8221; 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